Ethics in International Affairs IRL4527 L, Adibayeva Aigul

1. The health and well-being of animals. 2. The ethical obligation to protect and promote animal welfare in research. Factors affecting animal welfare include: food, water, housing, climate, mental stimulation, and freedom from pain, suffering, disease, and disability. See also Three Rs.

the view that (non-human) animals have moral or legal rights. Proponents of animal rights tend to regard animal experimentation as unethical because animals cannot consent to research.

see Institutional animal care and use committee.

a change to a human subjects research protocol approved by an institutional review board or the board’s chair (if the change is minor).

a medically undesirable event occurring in a research subject, such as an abnormal sign, symptom, worsening of a disease, injury, etc. A serious adverse event (SAE) results in death, hospitalization (or increased hospital stay), persistent disability, birth defect, or any other outcome that seriously jeopardizes the subject’s health. AEs which are also unanticipated problems should be reported promptly to institutional review boards and other appropriate officials.

a process in which an accrediting body determines whether an institution or organization meets certain standards developed by the body. For example, the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) accredits animal research programs, and the Association for the Accreditation of Human Research Protection Programs (AAHRPP) accredits human subjects research programs.

taking personal responsibility for one’s conduct